Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
Systems chronotherapeutics
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
Protecting the melatonin rhythm through circadian healthy light exposure
MA Bonmati-Carrion, R Arguelles-Prieto… - International journal of …, 2014 - mdpi.com
Currently, in developed countries, nights are excessively illuminated (light at night), whereas
daytime is mainly spent indoors, and thus people are exposed to much lower light intensities …
daytime is mainly spent indoors, and thus people are exposed to much lower light intensities …
Dosing-time makes the poison: circadian regulation and pharmacotherapy
R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
Circadian timing of metabolism in animal models and humans
C Dibner, U Schibler - Journal of internal medicine, 2015 - Wiley Online Library
Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …
their environment that are generated by the E arth's rotation. In the course of evolution, these …
[HTML][HTML] The use of wearables in clinical trials during cancer treatment: systematic review
UL Beauchamp, H Pappot… - JMIR mHealth and …, 2020 - mhealth.jmir.org
Background: Interest in the use of wearables in medical care is increasing. Wearables can
be used to monitor different variables, such as vital signs and physical activity. A crucial …
be used to monitor different variables, such as vital signs and physical activity. A crucial …
The circadian timing system in clinical oncology
The circadian timing system (CTS) controls several critical molecular pathways for cancer
processes and treatment effects over the 24 hours, including drug metabolism, cell cycle …
processes and treatment effects over the 24 hours, including drug metabolism, cell cycle …
The impact of schedule consistency on shift worker productivity: An empirical investigation
Problem definition: Lawmakers have begun to introduce “fair schedule” legislations that
require employers to provide shift workers with more predictable and consistent work …
require employers to provide shift workers with more predictable and consistent work …
Sex‐dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: randomized multicenter EORTC 05011 …
PF Innominato, A Ballesta, Q Huang, C Focan… - Cancer …, 2020 - Wiley Online Library
The least toxic time (LTT) of irinotecan varied by up to 8 hours according to sex and genetic
background in mice. The translational relevance was investigated within a randomized trial …
background in mice. The translational relevance was investigated within a randomized trial …
Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy
The circadian timing system (CTS) controls various biological functions in mammals
including xenobiotic metabolism and detoxification, immune functions, cell cycle events …
including xenobiotic metabolism and detoxification, immune functions, cell cycle events …