Dissecting the complexities of Alzheimer disease with in vitro models of the human brain
Alzheimer disease (AD) is the most prevalent type of dementia. It is marked by severe
memory loss and cognitive decline, and currently has limited effective treatment options …
memory loss and cognitive decline, and currently has limited effective treatment options …
[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease–associated genes
A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …
contribution of each variant to disease mechanism remains largely unknown. We have …
Presenilin-1 (PSEN1) mutations: clinical phenotypes beyond Alzheimer's disease
Y Yang, E Bagyinszky, SSA An - International Journal of Molecular …, 2023 - mdpi.com
Presenilin 1 (PSEN1) is a part of the gamma secretase complex with several interacting
substrates, including amyloid precursor protein (APP), Notch, adhesion proteins and beta …
substrates, including amyloid precursor protein (APP), Notch, adhesion proteins and beta …
The links between cardiovascular diseases and Alzheimer's disease
J Leszek, EV Mikhaylenko, DM Belousov… - Current …, 2021 - ingentaconnect.com
The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …
hundreds of research studies performed to attempt to solve this problem. Since proper …
Potential fluid biomarkers for the diagnosis of mild cognitive impairment
Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is
lower than normal for a person's age, but a higher function than that that observed in a …
lower than normal for a person's age, but a higher function than that that observed in a …
Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone
Abstract Background The United States is currently facing an opioid crisis. Novel tools to
better comprehend dynamic molecular changes in the brain associated with the opioid …
better comprehend dynamic molecular changes in the brain associated with the opioid …
CSF1R-related disorder: state of the art, challenges, and proposition of a new terminology
J Dulski, K Muthusamy, TC Lund, ZK Wszolek - Parkinsonism & Related …, 2024 - Elsevier
Recent developments in adult-onset leukoencephalopathy with axonal spheroids and
pigmented glia (ALSP) and other disorders due to CSF1R variants led to the emergence of …
pigmented glia (ALSP) and other disorders due to CSF1R variants led to the emergence of …
Metabolic disorder in Alzheimer's disease
Abstract Alzheimer's disease (AD), a well known aging-induced neurodegenerative disease
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …
APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease
The number of patients with Alzheimer's disease (AD) is rapidly increasing in Asia.
Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 …
Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 …