Insect guts present distinctive environments for microbial colonization, and bacteria in the
gut potentially provide many beneficial services to their hosts. Insects display a wide range …

The multifaceted innate immune system of insects is capable of fighting infection by a variety
of pathogens including those causing human malaria. Malaria transmission by the …

Transmission of malaria is dependent on the successful completion of the Plasmodium
lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue …

Activation of the insect innate immune system is dependent on a limited number of pattern
recognition receptors (PRRs) capable of interacting with pathogen-associated molecular …

In much of Africa, the mosquito Anopheles gambiae is the major vector of human malaria, a
devastating infectious disease caused by Plasmodium parasites. Vector and parasite …

The fibrinogen-related protein family (FREP, also known as FBN) is an evolutionarily
conserved immune gene family found in mammals and invertebrates. It is the largest pattern …

The virulence of pathogenic bacteria is dependent on their adaptation to and survival in the
stressful conditions encountered in their hosts. Helicobacter pylori exclusively colonizes the …

We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi
and Anopheles gambiae using phylogenetic, molecular, reverse genetic, and cell biological …

Mosquitoes are responsible for the transmission of diseases with a serious impact on global
human health, such as malaria and dengue. All mosquito-transmitted pathogens complete …

The resurgence of malaria is at least partly attributed to the absence of an effective vaccine,
parasite resistance to antimalarial drugs and resistance to insecticides of the anopheline …