Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow
from a multipotent stem cell and terminating in a mature, enucleated erythrocyte. Altered red …

Myeloproliferative neoplasms (essential thrombocythemia, ET; polycythemia vera, PV;
myelofibrosis, MF) are monoclonal malignancies associated with genomic instability …

Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6
(HDAC6) controls JAK2 translation and protein stability and has been implicated in JAK2 …

The discovery of somatic mutations, primarily JAK2V617F and CALR, in classic BCR-ABL1-
negative myeloproliferative neoplasms (MPNs) has generated interest in the development of …

Gene expression profiling in Philadelphia-negative chronic myeloproliferative neoplasms
(MPNs) have unraveled significant deregulation of several immune and inflammation genes …

The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with
clonal myelopoiesis, elevated risk of death due to thrombotic complications, and …

Tumor cell populations display a remarkable extent of variability in non-genetic
characteristics such as DNA methylation, histone modification patterns, and differentiation …

Abstract Purpose of Review The purpose of the review was to provide a contemporary
update of novel agents and targets under investigation in myelofibrosis in the Janus kinase …

Introduction: Myelofibrosis (MF) is a Philadelphia chromosome-negative myeloproliferative
neoplasm (MPN). It can be sub-categorized into primary myelofibrosis, post polycythemia …

Progression of chronic kidney disease is a principal challenge in Nephrology, as effective
therapies to halt or even reverse established lesion are not available yet. While numerous …