Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
Reactive oxygen species bridge the gap between chronic inflammation and tumor development
W Yu, Y Tu, Z Long, J Liu, D Kong… - Oxidative medicine …, 2022 - Wiley Online Library
According to numerous animal studies, adverse environmental stimuli, including physical,
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …
Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in …
J Lin, S Cao, Y Wang, Y Hu, H Liu, J Li, J Chen… - Journal of Experimental …, 2018 - Springer
Background Angiogenesis is considered as an important process in the development of
malignancies and is associated with cancer progression and metastasis. Hepatocellular …
malignancies and is associated with cancer progression and metastasis. Hepatocellular …
[HTML][HTML] Photodynamic therapy for inflammatory and cancerous diseases of the intestines: molecular mechanisms and prospects for application
B Deng, K Wang, L Zhang, Z Qiu, W Dong… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT) is a minimally invasive treatment that effectively targets cancer
and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and …
and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and …
Metronomic photodynamic therapy with conjugated polymer nanoparticles in glioblastoma tumor microenvironment
MD Caverzán, PM Oliveda, L Beaugé, RE Palacios… - Cells, 2023 - mdpi.com
Alternative therapies such as photodynamic therapy (PDT) that combine light, oxygen and
photosensitizers (PSs) have been proposed for glioblastoma (GBM) management to …
photosensitizers (PSs) have been proposed for glioblastoma (GBM) management to …
Autophagy regulation and photodynamic therapy: Insights to improve outcomes of cancer treatment
WK Martins, R Belotto, MN Silva, D Grasso… - Frontiers in …, 2021 - frontiersin.org
Cancer is considered an age-related disease that, over the next 10 years, will become the
most prevalent health problem worldwide. Although cancer therapy has remarkably …
most prevalent health problem worldwide. Although cancer therapy has remarkably …
In order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?
K McNicholas, MN MacGregor, JM Gleadle - British Journal of Cancer, 2019 - nature.com
Photodynamic diagnosis and therapy have emerged as a promising tool in oncology. Using
the visible fluorescence from photosensitisers excited by light, clinicians can both identify …
the visible fluorescence from photosensitisers excited by light, clinicians can both identify …
Photodynamic therapy in cancer stem cells—State of the art
AMC Ibarra, EMG Aguiar, CBR Ferreira… - Lasers in Medical …, 2023 - Springer
Despite significant efforts to control cancer progression and to improve oncology treatment
outcomes, recurrence and tumor resistance are frequently observed in cancer patients …
outcomes, recurrence and tumor resistance are frequently observed in cancer patients …
[HTML][HTML] Photodynamic therapy of Glioblastoma cells using doped conjugated polymer nanoparticles: An in vitro comparative study based on redox status
MD Caverzán, L Beaugé, CA Chesta… - … of Photochemistry and …, 2020 - Elsevier
Due to their superb light absorption and photostability conjugated polymer nanoparticles are
promising photosensitizers (PS) for their use in Photodynamic therapy (PDT). Recently, we …
promising photosensitizers (PS) for their use in Photodynamic therapy (PDT). Recently, we …
Enhanced anti-tumor efficacy by inhibiting HIF-1α to reprogram TAMs via core-satellite upconverting nanoparticles with curcumin mediated photodynamic therapy
LJ Zhang, R Huang, YW Shen, J Liu, Y Wu… - Biomaterials …, 2021 - pubs.rsc.org
Tumor hypoxic stress after photodynamic therapy (PDT) will be inevitably exacerbated by
the vascular blocking effects and oxygen consumption in the tumor microenvironment (TME) …
the vascular blocking effects and oxygen consumption in the tumor microenvironment (TME) …