Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Reactive oxygen species bridge the gap between chronic inflammation and tumor development

W Yu, Y Tu, Z Long, J Liu, D Kong… - Oxidative medicine …, 2022 - Wiley Online Library
According to numerous animal studies, adverse environmental stimuli, including physical,
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …

Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in …

J Lin, S Cao, Y Wang, Y Hu, H Liu, J Li, J Chen… - Journal of Experimental …, 2018 - Springer
Background Angiogenesis is considered as an important process in the development of
malignancies and is associated with cancer progression and metastasis. Hepatocellular …

[HTML][HTML] Photodynamic therapy for inflammatory and cancerous diseases of the intestines: molecular mechanisms and prospects for application

B Deng, K Wang, L Zhang, Z Qiu, W Dong… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT) is a minimally invasive treatment that effectively targets cancer
and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and …

Metronomic photodynamic therapy with conjugated polymer nanoparticles in glioblastoma tumor microenvironment

MD Caverzán, PM Oliveda, L Beaugé, RE Palacios… - Cells, 2023 - mdpi.com
Alternative therapies such as photodynamic therapy (PDT) that combine light, oxygen and
photosensitizers (PSs) have been proposed for glioblastoma (GBM) management to …

Autophagy regulation and photodynamic therapy: Insights to improve outcomes of cancer treatment

WK Martins, R Belotto, MN Silva, D Grasso… - Frontiers in …, 2021 - frontiersin.org
Cancer is considered an age-related disease that, over the next 10 years, will become the
most prevalent health problem worldwide. Although cancer therapy has remarkably …

In order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?

K McNicholas, MN MacGregor, JM Gleadle - British Journal of Cancer, 2019 - nature.com
Photodynamic diagnosis and therapy have emerged as a promising tool in oncology. Using
the visible fluorescence from photosensitisers excited by light, clinicians can both identify …

Photodynamic therapy in cancer stem cells—State of the art

AMC Ibarra, EMG Aguiar, CBR Ferreira… - Lasers in Medical …, 2023 - Springer
Despite significant efforts to control cancer progression and to improve oncology treatment
outcomes, recurrence and tumor resistance are frequently observed in cancer patients …

[HTML][HTML] Photodynamic therapy of Glioblastoma cells using doped conjugated polymer nanoparticles: An in vitro comparative study based on redox status

MD Caverzán, L Beaugé, CA Chesta… - … of Photochemistry and …, 2020 - Elsevier
Due to their superb light absorption and photostability conjugated polymer nanoparticles are
promising photosensitizers (PS) for their use in Photodynamic therapy (PDT). Recently, we …

Enhanced anti-tumor efficacy by inhibiting HIF-1α to reprogram TAMs via core-satellite upconverting nanoparticles with curcumin mediated photodynamic therapy

LJ Zhang, R Huang, YW Shen, J Liu, Y Wu… - Biomaterials …, 2021 - pubs.rsc.org
Tumor hypoxic stress after photodynamic therapy (PDT) will be inevitably exacerbated by
the vascular blocking effects and oxygen consumption in the tumor microenvironment (TME) …