Small-ring heterocycles have found many applications both as useful starting materials in
the synthesis of more elaborate structures and as valuable targets of synthesis. Our review …

Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

More than a decade ago, the question was raised by Sweeney if aziridines are epoxides'
ugly cousins? 1 The overview on the biological properties, synthetic accessibility, and useful …

A new class of stable molecules, α-boryl aldehydes, has been prepared from oxiranyl N-
methyliminodiacetyl boronates by a 1, 2-boryl migration with concomitant epoxide scission …

Small cyclic peptides possess a wide range of biological properties and unique structures
that make them attractive to scientists working in a range of areas from medicinal to …

Conspectus Researchers continue to develop chemoselective synthesis strategies with the
goal of rapidly assembling complex molecules. As one appealing approach, chemists are …

Entry to bioactive boropeptides: MIDA‐containing α‐boryl isocyanides are isolable
molecules which allow one‐step access to boroalkyl‐functionalized heterocycles as well as …

Triazole tethers have been explored for stabilization of secondary structures in peptides.
Despite the utility of this approach, cyclization efficiency in complex peptides remains a …

We have developed a strategy for synthesizing passively permeable peptidomimetic
macrocycles. The cyclization chemistry centers on using aziridine aldehydes in a …