Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Cellular senescence, characterized by stable cell cycle arrest, plays an important role in
aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged …

Immune responses are directed by the complex interactions of different cell types, including
T cells and Natural Killer (NK) cells, with a key type of interaction being the formation of …

Tumor cells metastasize to distant organs mainly via hematogenous dissemination, in which
circulating tumor cells (CTCs) are relatively vulnerable, and eliminating these cells has great …

Mechanical forces in the tumor microenvironment (TME) are associated with tumor growth,
proliferation, and drug resistance. Strong mechanical forces in tumors alter the metabolism …

Simple Summary The immune system provides surveillance measures to identify and
remove damaged cell types at an early stage. One important example involves the NKG2D …

Background One critical component of the immune system that prevents breast cancer cells
from forming distant metastasis is natural killer (NK) cells participating in immune responses …

Within the complex tumor microenvironment, cells experience mechanical cues—such as
extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, and fluid …

Simple Summary Glioblastoma is the most prevalent cerebral cancer in adults without
proven therapy. Chimeric antigen receptor T cell treatment has demonstrated good clinical …

Natural killer (NK) cells and CD8+ T cells can clear infected and transformed cells and
generate tolerance to themselves, which also prevents autoimmune diseases. Natural killer …