[HTML][HTML] Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration
SK Jha, NK Jha, D Kumar, RK Ambasta… - Biochimica et Biophysica …, 2017 - Elsevier
Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes,
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …
The multifaceted role of vitamin B6 in cancer: Drosophila as a model system to investigate DNA damage
R Contestabile, ML di Salvo, V Bunik… - Open …, 2020 - royalsocietypublishing.org
A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different
human diseases, including cancer and neurological disorders. Several data converge …
human diseases, including cancer and neurological disorders. Several data converge …
Neuroprotective potential of flavonoid rich Ascophyllum nodosum (FRAN) fraction from the brown seaweed on an Aβ42 induced Alzheimer's model of Drosophila
Abstract Background In Alzheimer Disease (AD) pathogenesis, aggregation of Aβ 42 fibrils
strongly correlates with memory dysfunction and neurotoxicity. Till date, no promising cures …
strongly correlates with memory dysfunction and neurotoxicity. Till date, no promising cures …
Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models
FJ Sanz, C Solana-Manrique, V Muñoz-Soriano… - Free Radical Biology …, 2017 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. It is caused by a loss of dopaminergic neurons in the substantia nigra …
Alzheimer's disease. It is caused by a loss of dopaminergic neurons in the substantia nigra …
The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster
Background Genetic association studies that seek to explain the inheritance of complex
traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are …
traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are …
[HTML][HTML] Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model
Introduction Mitochondrial defects have been implicated in Parkinson's disease (PD) since
complex I poisons were found to cause accelerated parkinsonism in young people in the …
complex I poisons were found to cause accelerated parkinsonism in young people in the …
Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples
Folic acid (FA) is an important vitamin for human growth and development, especially for
pregnant women. A sensitive, rapid, and accurate FA detection method is required to assess …
pregnant women. A sensitive, rapid, and accurate FA detection method is required to assess …
LC-Orbitrap HRMS-Based Proteomics Reveals Novel Mitochondrial Dynamics Regulatory Proteins Associated with Ras V12-Induced Glioblastoma (GBM) of …
Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor found in
adult humans with a poor prognosis and average survival of 14–15 months. In order to have …
adult humans with a poor prognosis and average survival of 14–15 months. In order to have …
Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy
The synaptic protein α-synuclein is linked through genetics and neuropathology to the
pathogenesis of Parkinson's disease and related disorders. However, the mechanisms by …
pathogenesis of Parkinson's disease and related disorders. However, the mechanisms by …
Folic Acid Improves Parkin-Null Drosophila Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and …
KL Houlihan, PP Keoseyan, AN Juba, T Margaryan… - Antioxidants, 2022 - mdpi.com
Loss-of-function parkin mutations cause oxidative stress and degeneration of dopaminergic
neurons in the substantia nigra. Several consequences of parkin mutations have been …
neurons in the substantia nigra. Several consequences of parkin mutations have been …