Background & Aims Intratumor heterogeneity and divergent clonal lineages within and
among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to …

Background Recent studies have reported that Integrin alpha 2 (ITGA2) plays an essential
role in tumor cell proliferation, invasion, metastasis, and angiogenesis. An abnormally …

Purpose: Chemoresistance is the main cause of treatment failure in cancer and is
associated with distant metastases and epithelial-to-mesenchymal transition (EMT). This …

Background Integrins are integral to cell signalling and management of the extracellular
matrix, and exquisite regulation of their expression is essential for a variety of cell signalling …

Background Gastric cancer is currently the fourth leading cause of cancer-related death
worldwide. Gastric cancer is often diagnosed at advanced stages and the outcome of the …

The incidence rate of human uterine leiomyomas is over 70% in the women of childbearing
age, which has caused serious health and financial burden. Our previous study confirmed …

The loss of ITGA2 plays an important role in cancer metastasis in several solid cancers.
However, the molecular mechanism of ITGA2 loss in primary cancers remains unclear. In …

Intrahepatic cholangiocarcinoma (iCCA) arises along the peripheral bile ducts and is often
accompanied by a tumor microenvironment (TME) high in extracellular matrices (ECMs). In …

Pancreatic cancer (PC) is recognized as the most aggressive and deadliest malignancy
because it has the highest mortality of all cancers in humans. Mutations in multiple tumor …

The present study aimed to investigate the roles of Ropivacaine in papillary thyroid cancer
(PTC) and identify the possible mechanisms. The expression of integrin alpha‐2 (ITGA2) in …