Glioma targeted therapy: insight into future of molecular approaches

K Yang, Z Wu, H Zhang, N Zhang, W Wu, Z Wang… - Molecular Cancer, 2022 - Springer
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

L Kraehenbuehl, CH Weng, S Eghbali… - Nature reviews Clinical …, 2022 - nature.com
The discovery and clinical implementation of immune-checkpoint inhibitors (ICIs) targeting
CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as recognized by the …

Immune checkpoint signaling and cancer immunotherapy

X He, C Xu - Cell research, 2020 - nature.com
Immune checkpoint blockade therapy has become a major weapon in fighting cancer.
Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such …

cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

ST Ferris, V Durai, R Wu, DJ Theisen, JP Ward… - Nature, 2020 - nature.com
Conventional type 1 dendritic cells (cDC1) are thought to perform antigen cross-
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

S Qin, L Xu, M Yi, S Yu, K Wu, S Luo - Molecular cancer, 2019 - Springer
The emergence of immune checkpoint inhibitors (ICIs), mainly including anti-programmed
cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anti-cytotoxic T …

[HTML][HTML] Phenotypic signatures of immune selection in HIV-1 reservoir cells

W Sun, C Gao, CA Hartana, MR Osborn, KB Einkauf… - Nature, 2023 - nature.com
Abstract Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite
antiretroviral treatment, but may be vulnerable to host immune responses that could be …

Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis

Z Huang, B Chen, X Liu, H Li, L Xie… - Proceedings of the …, 2021 - National Acad Sciences
Sex and aging influence the human immune system, resulting in disparate responses to
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …

Immune checkpoint proteins: Signaling mechanisms and molecular interactions in cancer immunotherapy

S Gaikwad, MY Agrawal, I Kaushik… - Seminars in cancer …, 2022 - Elsevier
Immune checkpoint proteins (ICP) are currently one of the most novel and promising areas
of immune-oncology research. This novel way of targeting tumor cells has shown favorable …

Immune checkpoint blockade in infectious diseases

MN Wykes, SR Lewin - Nature Reviews Immunology, 2018 - nature.com
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …

Beyond the anti-PD-1/PD-L1 era: promising role of the BTLA/HVEM axis as a future target for cancer immunotherapy

C Sordo-Bahamonde, S Lorenzo-Herrero… - Molecular Cancer, 2023 - Springer
Recent introduction of monoclonal antibodies targeting immune checkpoints to harness
antitumor immunity has revolutionized the cancer treatment landscape. The therapeutic …