Nitric oxide as a central molecule in hypertension: Focus on the vasorelaxant activity of new nitric oxide donors

GM da Silva, MC da Silva, DVG Nascimento… - Biology, 2021 - mdpi.com
Simple Summary Nitric oxide is an important molecule that performs a variety of functions in
our bodies, especially in the cardiovascular system. In certain pathological conditions, such …

The latest advances in the discovery of nitric oxide hybrid drug compounds

RAM Serafim, FG Pernichelle… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: There is a great interest in Nitric oxide (NO) within medicinal chemistry since it's
involved in human signaling pathways. Prodrugs or hybrid compounds containing NO-donor …

[HTML][HTML] Proteolysis in goat “coalho” cheese supplemented with probiotic lactic acid bacteria

TKA Bezerra, ARR de Araujo, ES do Nascimento… - Food Chemistry, 2016 - Elsevier
This study aimed to analyse the proteolytic effects of adding isolated and combined probiotic
strains to goat “coalho” cheese. The cheeses were: QS–with culture Start, composed by …

Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR

LA Perassa, ME Graton, SR Potje, JA Troiano… - Vascular …, 2016 - Elsevier
This study has evaluated how the vascular endothelium of hypertensive rats chronically
treated with apocynin affects acetylcholine (ACh), sodium nitroprusside (SNP), and …

Overview of antagonists used for determining the mechanisms of action employed by potential vasodilators with their suggested signaling pathways

YC Loh, CS Tan, YS Ch'ng, M Ahmad, MZ Asmawi… - Molecules, 2016 - mdpi.com
This paper is a review on the types of antagonists and the signaling mechanism pathways
that have been used to determine the mechanisms of action employed for vasodilation by …

Gut microbiota perturbation in early life could Influence Pediatric blood pressure regulation in a sex-dependent manner in juvenile rats

Y Yang, J Li, Z Zhou, S Wu, J Zhao, W Jia, M Liu… - Nutrients, 2023 - mdpi.com
The present study aimed to investigate whether gut dysbiosis induced by ceftriaxone in early
life could influence pediatric blood pressure regulation in childhood with or without exposure …

[HTML][HTML] The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats

LL Paulo, JC Cruz, Z Zhuge, A Carvalho-Galvão… - Redox Biology, 2018 - Elsevier
Rationale Development and progression of cardiovascular diseases, including
hypertension, are often associated with impaired nitric oxide synthase (NOS) function and …

Apocynin alters redox signaling in conductance and resistance vessels of spontaneously hypertensive rats

ME Graton, SR Potje, JA Troiano, GT Vale… - Free Radical Biology …, 2019 - Elsevier
Chronic treatment with apocynin reduces blood pressure and prevents endothelial
dysfunction development in spontaneously hypertensive rats (SHR). Mechanisms …

Anti-hypertensive property of a nickel-piperazine/NO donor in spontaneously hypertensive rats

M Monti, V Ciccone, A Pacini, R Roggeri… - Pharmacological …, 2016 - Elsevier
The nickel-piperazine/NO donor compound, Ni (PipNONO) Cl, belonging to the family of
compounds labelled as⿿ metal-nonoates⿿, due to its promising vasodilating activity, has …

Nitric oxide signaling and the cross talk with prostanoids pathways in vascular system

BR Silva, TD Paula, M Paulo… - Medicinal …, 2017 - ingentaconnect.com
Background: This review provides an overview of the cellular signaling of nitric oxide (NO)
and prostanoids in vascular cells and the possible cross talk between their pathways, mainly …