The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Prostate tumors are among the most heterogeneous of cancers, both histologically and
clinically. Microarray expression analysis was used to determine whether global biological …

Purpose The incidence of prostate cancer is frequent, occurring in almost one-third of men
older than 45 years. Only a fraction of the cases reach the stages displaying clinical …

Background Prostate cancer is characterized by heterogeneity in the clinical course that
often does not correlate with morphologic features of the tumor. Metastasis reflects the most …

The type 1 insulin-like growth factor receptor (IGF1R) mediates tumor cellgrowth, adhesion,
and protection from apoptosis. High plasma IGF-I levels predispose to prostate cancer, but …

BACKGROUND Monocyte chemotactic protein‐1 (MCP‐1) plays a key role in the
recruitment and activation of monocytes during inflammation. Increased MCP‐1 serum …

In many cases, silencing of gene expression by CpG methylation is causally involved in
carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor …

Prostate cancer is a biologically heterogeneous disease with considerable variation in
clinical aggressiveness. The behavior of prostate cancer can be considered a direct or …

Background: Metastatic prostate cancer (PCa) has no curative treatment options. Some
forms of PCa are indolent and slow growing, while others metastasise quickly and may …