Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …
tumors are now well characterized. However, recent evidence has shown that these cells …
Human prostate cancer risk factors
DG Bostwick, HB Burke, D Djakiew… - … Journal of the …, 2004 - Wiley Online Library
Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …
similar likelihood of neoplastic foci found within the prostates of men around the world …
[HTML][HTML] Gene expression correlates of clinical prostate cancer behavior
Prostate tumors are among the most heterogeneous of cancers, both histologically and
clinically. Microarray expression analysis was used to determine whether global biological …
clinically. Microarray expression analysis was used to determine whether global biological …
Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
YP Yu, D Landsittel, L Jing, J Nelson, B Ren… - Journal of clinical …, 2004 - ascopubs.org
Purpose The incidence of prostate cancer is frequent, occurring in almost one-third of men
older than 45 years. Only a fraction of the cases reach the stages displaying clinical …
older than 45 years. Only a fraction of the cases reach the stages displaying clinical …
[HTML][HTML] Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
UR Chandran, C Ma, R Dhir, M Bisceglia… - BMC cancer, 2007 - Springer
Background Prostate cancer is characterized by heterogeneity in the clinical course that
often does not correlate with morphologic features of the tumor. Metastasis reflects the most …
often does not correlate with morphologic features of the tumor. Metastasis reflects the most …
Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
GO Hellawell, GDH Turner, DR Davies, R Poulsom… - Cancer research, 2002 - AACR
The type 1 insulin-like growth factor receptor (IGF1R) mediates tumor cellgrowth, adhesion,
and protection from apoptosis. High plasma IGF-I levels predispose to prostate cancer, but …
and protection from apoptosis. High plasma IGF-I levels predispose to prostate cancer, but …
Monocyte chemotactic protein‐1 (MCP‐1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion
BACKGROUND Monocyte chemotactic protein‐1 (MCP‐1) plays a key role in the
recruitment and activation of monocytes during inflammation. Increased MCP‐1 serum …
recruitment and activation of monocytes during inflammation. Increased MCP‐1 serum …
Functional epigenomics identifies genes frequently silenced in prostate cancer
In many cases, silencing of gene expression by CpG methylation is causally involved in
carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor …
carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor …
Gene expression analysis of prostate cancers
JH Luo, YP Yu, K Cieply, F Lin… - … in cooperation with …, 2002 - Wiley Online Library
Prostate cancer is a biologically heterogeneous disease with considerable variation in
clinical aggressiveness. The behavior of prostate cancer can be considered a direct or …
clinical aggressiveness. The behavior of prostate cancer can be considered a direct or …
[HTML][HTML] Identification of markers of prostate cancer progression using candidate gene expression
SET Larkin, S Holmes, IA Cree, T Walker… - British journal of …, 2012 - nature.com
Background: Metastatic prostate cancer (PCa) has no curative treatment options. Some
forms of PCa are indolent and slow growing, while others metastasise quickly and may …
forms of PCa are indolent and slow growing, while others metastasise quickly and may …