Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for
millisecond resolution control of neural activity. By targeting opsin expression to specific cell …

Perrault syndrome is a genetically and clinically heterogeneous autosomal-recessive
condition characterized by sensorineural hearing loss and ovarian failure. By a combination …

▪ Abstract The GoLoco motif is a 19-amino-acid sequence with guanine nucleotide
dissociation inhibitor activity against G-alpha subunits of the adenylyl-cyclase-inhibitory …

▪ Abstract Accessory proteins involved in signal processing through heterotrimeric G proteins
are generally defined as proteins distinct from G protein–coupled receptor (GPCR), G …

The cerebellum provides an excellent system for understanding how afferent and target
neurons coordinate sequential intercellular signals and cell-autonomous genetic programs …

Guanine nucleotide-binding proteins, G proteins, propagate incoming messages from
receptors to effector proteins. They switch from an inactive to active state by exchanging a …

The cerebellum plays a critical role in all vertebrates, and many neurological disorders are
associated with cerebellum dysfunction. A major limitation in cerebellar research has been …

Cell-type-specific promoters in combination with viral vectors and gene-editing technology
permit efficient gene manipulation in specific cell populations. Cerebellar Purkinje cells play …

Continuous in vivo monitoring (CIVM) of pH value is essential for personalized medicine, as
many diseases are closely related to acid–base imbalances. However, conventional pH …