The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory
modulator of glial activation, preventing inflammation-mediated neuronal degeneration …

Objective Solid tumours respond poorly to immune checkpoint inhibitor (ICI) therapies. One
major therapeutic obstacle is the immunosuppressive tumour microenvironment (TME) …

Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …

As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous
cell population with significant cellular phenotypic and functional plasticity. They form a …

Marching into the second decade after the approval of ipilimumab, it is clear that immune
checkpoint inhibitors (ICIs) have dramatically improved the prognosis of melanoma …

Commensal bacteria are necessary for the development and maintenance of a healthy
immune system. Harnessing the ability of microbiota to affect host immunity is considered an …