Extrinsic skin aging is superimposed on intrinsic skin aging process and is due primarily to
UVR (solar ultraviolet radiation) and partly by other factors, such as infrared light, smoking …

Abstract Cyclooxygenase (COX)-derived prostaglandins (PGs) exhibit manifold functions in
acute and chronic skin inflammation induced by a number of physical (ultraviolet (UV) light …

The cyclooxygenase isoforms, COX-1 and COX-2, are involved in the biosynthesis of
prostaglandin E 2, a major prostaglandin involved in epidermal homeostasis and repair …

UV radiation induces systemic immunosuppression. Because nonsteroidal anti-inflammatory
drugs suppress UV-induced immunosuppression, prostanoids have been suspected as a …

Ultraviolet B (UVB) radiation causes much of the cutaneous damage after both acute and
long-term exposure, and is also the most important etiologic agent in human skin cancer …

Keratinocytes are the major target of sunlight, and they produce prostaglandin (PG) E 2
upon ultraviolet (UV) exposure. Although indomethacin, one of cyclooxygenase inhibitors, is …

Xeroderma pigmentosum complementation group A is a hereditary disease characterized by
early onset of skin cancers and freckle-like pigmented maculae in sun-exposed sites …

Because selective inhibition of cyclooxygenase‐2 (COX‐2) suppressed the induction of skin
tumors in mice by UV and as UV has been shown to induce expression of COX‐2 in skin …

Exposure of mice to UV radiation results in suppression of the contact hypersensitivity (CHS)
response. Here, we report that the UV-induced suppression of CHS is associated with …

In this study, we investigated the time-dependent expression of IL-1β, COX-2, MCP-1 mRNA
after incised wounds in rabbit skin using real-time fluorescent quantitative PCR. The tested …