Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. Until recently, the underlying cause was known in only a minority of cases that were …

Stroke, resulting from limited blood flow to the brain, is one of the most important causes of
morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase originally identified as a
regulator of glycogen metabolism but it also plays a pivotal role in numerous cellular …

Progranulin (PGRN) is known to play a role in the pathogenesis of neurodegenerative
diseases. Recently, it has been demonstrated that patients with the homozygous mutation in …

There is a well-established link between cytokine expression and the progression of
intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor …

Ischemic stroke is a leading cause of mortality and disability worldwide. Nevertheless, its
molecular mechanisms have not yet been adequately illustrated. Progranulin (PGRN) is a …

Depression is one of the most common and debilitating psychiatric illnesses around the
world, but the current antidepressants used to treat depression have many limitations …

Progranulin (PGRN) is a protein with multiple functions including the regulation of
neuroinflammation, neuronal survival, neurite and synapsis growth. Although the …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
tremor, rigidity and akinesia/bradykinesia resulting from the progressive loss of nigrostriatal …