Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the
lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective …

Injured neurons in the adult mammalian central nervous system often die and seldom
regenerate axons. To uncover transcriptional pathways that could ameliorate these …

Axons in the mammalian CNS fail to regenerate after injury. Here we show that if the activity
of mouse retinal ganglion cells (RGCs) is increased by visual stimulation or using …

Highlights•Nogo-A limits neural repair and recovery after adult CNS injuries.•NgR1 and
S1PR2 are receptors for different domains of Nogo-A.•Nogo-A and NgR1 limit experience …

Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

Although a number of repair strategies have been shown to promote axon outgrowth
following neuronal injury in the mammalian CNS, it remains unclear whether regenerated …

Neurons differ in their responses to injury, but the underlying mechanisms remain poorly
understood. Using quantitative proteomics, we characterized the injury-triggered response …

The optic nerve has been widely used to investigate factors that regulate axon regeneration
in the mammalian CNS. Although retinal ganglion cells (RGCs), the projection neurons of …