In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Background & Aims We performed a systematic review and meta-analysis to
comprehensively estimate adenoma miss rate (AMR) and advanced AMR (AAMR) and …

Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of
well-characterized genetic and epigenetic alterations. We review the genetic changes …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …

Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Background & Aims Serrated polyps (SPs) and conventional adenomas are precursor
lesions for colorectal cancer (CRC), but they are believed to arise via distinct pathways. We …