Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …

Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing
dysfunctional ECM could potentially prevent age-related pathologies. Interventions …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

Maintenance of a functional proteome is achieved through the mechanism of proteostasis
that involves precise coordination between molecular machineries assisting a protein from …

Germline regulates the expression of life‐history traits and mediates the trade‐off between
reproduction and somatic maintenance. However, germline maintenance in itself can be …

Understanding the molecular events that regulate cell pluripotency versus acquisition of
differentiated somatic cell fate is fundamentally important. Studies in Caenorhabditis …

The reproductive system regulates somatic aging through competing anti-and pro-aging
signals. Germline removal extends somatic lifespan through conserved pathways including …

Aging animals accumulate insoluble proteins as a consequence of a decline of proteostatic
maintenance with age. In Caenorhabditis elegans, for instance, levels of detergent-insoluble …

The quality control machinery regulates the cellular proteome to ensure proper protein
homeostasis (proteostasis). In Caenorhabditis elegans, quality control networks are …