Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82
individuals (80 cases collated from the literature and two cases of his own) who had a …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules.
AR primarily is responsible for mediating the physiologic effects of androgens by binding to …

Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with
DNA are reported. The domain has a globular fold which contains two Zn-nucleated …

We report here the identification of thyroid hormone response elements (TREs) that consist
of a direct repeat, not a palindrome, of the half-sites. Unlike palindromic TREs, direct repeat …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

The estrogen receptor (ER) mediates most of the biological effects of estrogens at the level
of gene regulation by interacting through its site‐specific DNA and with other coregulatory …

The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding
transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific …