Genomic analyses are yielding a host of new information on the multiple genetic
abnormalities associated with specific types of cancer. A comprehensive description of …

Inorganic polyphosphate (polyP), the first high-energy compound on earth, defies its
extreme compositional and structural simplicity with an astoundingly wide array of biological …

Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling
cascades with other intracellular pathways in breast cancer could lead to massive abnormal …

Acute myeloid leukemia (AML) is one of the most common and deadly forms of
hematopoietic malignancies. We hypothesized that microarray studies could identify …

A lack of reliably informative biomarkers to distinguish indolent and lethal prostate cancer is
one reason this disease is overtreated. miR-221 has been suggested as a biomarker in high …

The DHH superfamily human protein h-prune, a binding partner of the metastasis
suppressor nm23-H1, is frequently overexpressed in metastatic cancers. From an …

Abstract h-prune, which has been suggested to be involved in cell migration, was identified
as a glycogen synthase kinase 3 (GSK-3)-binding protein. Treatment of cultured cells with …

Nm23-H1 significantly reduces metastasis without effects on primary tumor size and was the
first discovered metastasis suppressor gene. At least three mechanisms are thought to …

We describe here the molecular basis of the complex formation of PRUNE1 with the tumor
metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside …

Polyphosphate (polyP) is a ubiquitous biomolecule thought to be present in all cells on
Earth. PolyP is deceivingly simple, consisting of repeated units of inorganic phosphates …