Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases

P Celec, B Vlková, L Lauková, J Bábíčková… - Expert reviews in …, 2018 - cambridge.org
Cell-free DNA (cfDNA) is present in various body fluids and originates mostly from blood
cells. In specific conditions, circulating cfDNA might be derived from tumours, donor organs …

Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia-reperfusion rats

CX Shi, J Jin, XQ Wang, T Song… - Molecular …, 2020 - spandidos-publications.com
The present study aimed to investigate the effects of sevoflurane post-conditioning in a rat
brain cerebral ischemia-reperfusion (I/R) model and examine its possible mechanism. Rats …

Cell-free DNA as a biomarker in stroke: Current status, problems and perspectives

KV Glebova, NN Veiko, AA Nikonov… - Critical Reviews in …, 2018 - Taylor & Francis
There is currently no proposed stroke biomarker with consistent application in clinical
practice. A number of studies have examined cell-free DNA (cfDNA), which circulates in …

Chlorogenic acid alleviates cerebral ischemia-induced neuroinflammation via attenuating nuclear factor kappa B activation

MA Shah, JB Kang, DJ Park, MO Kim, PO Koh - Neuroscience Letters, 2022 - Elsevier
Ischemic stroke is the most common type of stroke and is caused by vascular closure.
Chlorogenic acid is a polyphenolic compound that is present in various plants. It is used as a …

Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2

Z Li, L Pang, F Fang, G Zhang, J Zhang, M Xie, L Wang - Brain research, 2012 - Elsevier
A number of studies have demonstrated that resveratrol (Res), a natural polyphenol
compound found in plants, shows potent neuroprotective, anti-inflammatory and antioxidant …

Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation

GC O'Connell, AB Petrone, CS Tennant… - Brain Injury, 2017 - Taylor & Francis
Objective: The objective of this work was to assess the ability of peripheral blood cell-free
DNA (cfDNA) levels to identify ischaemic stroke early in the acute phase of care, as well as …

TMEM16F aggravates neuronal loss by mediating microglial phagocytosis of neurons in a rat experimental cerebral ischemia and reperfusion model

Y Zhang, H Li, X Li, J Wu, T Xue, J Wu, H Shen… - Frontiers in …, 2020 - frontiersin.org
Cerebral ischemia is a severe, acute condition, normally caused by cerebrovascular
disease, and results in high rates of disability, and death. Phagoptosis is a newly recognized …

A novel method for assessing cerebral edema, infarcted zone and blood-brain barrier breakdown in a single post-stroke rodent brain

R Kuts, D Frank, BF Gruenbaum, J Grinshpun… - Frontiers in …, 2019 - frontiersin.org
Stroke is a major cause of global morbidity and mortality. Middle cerebral artery occlusion
(MCAO) has historically been the most common animal model of simulating ischemic stroke …

The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach

D Frank, R Kuts, P Tsenter, BF Gruenbaum… - …, 2019 - Elsevier
Post-stroke depression (PSD) is a common and serious complication following stroke. Both
stroke and depression have independently been associated with pathologically elevated …

Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis

JO Ström, E Ingberg, A Theodorsson, E Theodorsson - BMC neuroscience, 2013 - Springer
Background Even though more than 600 stroke treatments have been shown effective in
preclinical studies, clinically proven treatment alternatives for cerebral infarction remain …