The acute symptoms of gout are triggered by the inflammatory response to monosodium
urate crystals, mediated principally by macrophages and neutrophils. Innate immune …

Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

The termination of inflammation is governed by endogenous molecules collectively referred
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …

Gout, a chronic inflammatory arthritis disease, is characterized by hyperuricemia and caused
by interactions between genetic, epigenetic, and metabolic factors. Acute gout symptoms are …

In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is
known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation …

A complex intracellular signaling governs different cellular responses in inflammation.
Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular …

From development to aging and disease, the brain parenchyma is under the constant threat
of debris accumulation, in the form of dead cells and protein aggregates. To prevent …

Integrins constitute a large group of adhesion receptors that are formed as heterodimers of α
and β subunits. Their presence and activation status on the surface of leukocytes modulate a …

Streptococcus pneumoniae is a major cause of community‐acquired pneumonia leading to
high mortality rates. Inflammation triggered by pneumococcal infection is necessary for …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …