[HTML][HTML] Emerging critical roles of Fe–S clusters in DNA replication and repair
Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
Human apurinic/apyrimidinic endonuclease 1
M Li, DM Wilson III - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1)
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …
APE1: A skilled nucleic acid surgeon
AM Whitaker, BD Freudenthal - DNA repair, 2018 - Elsevier
Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion
must first be removed from the genome. This process of removing and replacing DNA …
must first be removed from the genome. This process of removing and replacing DNA …
Capturing snapshots of APE1 processing DNA damage
BD Freudenthal, WA Beard, MJ Cuneo… - Nature structural & …, 2015 - nature.com
DNA apurinic-apyrimidinic (AP) sites are prevalent noncoding threats to genomic stability
and are processed by AP endonuclease 1 (APE1). APE1 incises the AP-site phosphodiester …
and are processed by AP endonuclease 1 (APE1). APE1 incises the AP-site phosphodiester …
Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome
S Roychoudhury, S Pramanik… - Proceedings of the …, 2020 - National Acad Sciences
Formation of G-quadruplex (G4) DNA structures in key regulatory regions in the genome has
emerged as a secondary structure-based epigenetic mechanism for regulating multiple …
emerged as a secondary structure-based epigenetic mechanism for regulating multiple …
[HTML][HTML] Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair
J Lafrance-Vanasse, GJ Williams, JA Tainer - Progress in biophysics and …, 2015 - Elsevier
Abstract The Mre11-Rad50-Nbs1 (MRN) complex is a dynamic macromolecular machine
that acts in the first steps of DNA double strand break repair, and each of its components has …
that acts in the first steps of DNA double strand break repair, and each of its components has …
APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
TC Liu, CT Lin, KC Chang, KW Guo, S Wang… - Nature …, 2021 - nature.com
The exonuclease activity of Apurinic/apyrimidinic endonuclease 1 (APE1) is responsible for
processing matched/mismatched terminus in various DNA repair pathways and for removing …
processing matched/mismatched terminus in various DNA repair pathways and for removing …
Structural basis for APE1 processing DNA damage in the nucleosome
Genomic DNA is continually exposed to endogenous and exogenous factors that promote
DNA damage. Eukaryotic genomic DNA is packaged into nucleosomes, which present a …
DNA damage. Eukaryotic genomic DNA is packaged into nucleosomes, which present a …
Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance
DR McNeill, AM Whitaker, WJ Stark, JL Illuzzi… - …, 2020 - academic.oup.com
DNA is susceptible to a range of chemical modifications, with one of the most frequent
lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (eg …
lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (eg …
The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once
SE Tsutakawa, J Lafrance-Vanasse, JA Tainer - DNA repair, 2014 - Elsevier
To avoid genome instability, DNA repair nucleases must precisely target the correct
damaged substrate before they are licensed to incise. Damage identification is a challenge …
damaged substrate before they are licensed to incise. Damage identification is a challenge …