Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii
R Carballar-Lejarazú, Y Dong… - Proceedings of the …, 2023 - National Acad Sciences
Proposed genetic approaches for reducing human malaria include population modification,
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission …
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission …
Leveraging eco-evolutionary models for gene drive risk assessment
Engineered gene drives create potential for both widespread benefits and irreversible harms
to ecosystems. CRISPR-based systems of allelic conversion have rapidly accelerated gene …
to ecosystems. CRISPR-based systems of allelic conversion have rapidly accelerated gene …
The potential of gene drives in malaria vector species to control malaria in African environments
Gene drives are a promising means of malaria control with the potential to cause sustained
reductions in transmission. In real environments, however, their impacts will depend on local …
reductions in transmission. In real environments, however, their impacts will depend on local …
Assessing the impact of relapse, reinfection and recrudescence on malaria eradication policy: a bifurcation and optimal control analysis
In the present study, we propose and analyze an epidemic mathematical model for malaria
dynamics, considering multiple recurrent phenomena: relapse, reinfection, and …
dynamics, considering multiple recurrent phenomena: relapse, reinfection, and …
Transformative Approaches for Sustainable Weed Management: The Power of Gene Drive and CRISPR-Cas9
Weeds can negatively impact crop yields and the ecosystem's health. While many weed
management strategies have been developed and deployed, there is a greater need for the …
management strategies have been developed and deployed, there is a greater need for the …
Genetic and geographic population structure in the malaria vector, Anopheles farauti, provides a candidate system for pioneering confinable gene-drive releases
Indoor insecticide applications are the primary tool for reducing malaria transmission in the
Solomon Archipelago, a region where Anopheles farauti is the only common malaria vector …
Solomon Archipelago, a region where Anopheles farauti is the only common malaria vector …
MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance
A Mondal, HM Sánchez C… - PLOS Computational …, 2024 - journals.plos.org
Novel mosquito genetic control tools, such as CRISPR-based gene drives, hold great
promise in reducing the global burden of vector-borne diseases. As these technologies …
promise in reducing the global burden of vector-borne diseases. As these technologies …
Considerations for first field trials of low-threshold gene drive for malaria vector control
JB Connolly, A Burt, G Christophides, A Diabate… - Malaria Journal, 2024 - Springer
Sustainable reductions in African malaria transmission require innovative tools for mosquito
control. One proposal involves the use of low-threshold gene drive in Anopheles vector …
control. One proposal involves the use of low-threshold gene drive in Anopheles vector …
A model-informed target product profile for population modification gene drives for malaria control
A Mondal, HM Sanchez Castellanos, JM Marshall - medRxiv, 2024 - medrxiv.org
As reductions in malaria transmission in sub-Saharan Africa stagnate, gene drive-modified
mosquitoes represent one of the most promising novel tools for continued disease control. In …
mosquitoes represent one of the most promising novel tools for continued disease control. In …