ISPAD clinical practice consensus guidelines 2022: Stages of type 1 diabetes in children and
adolescents Page 1 ISPAD GUIDELINES ISPAD clinical practice consensus guidelines 2022 …

Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …

We analyzed the effects of a single 14-day course of teplizumab treatment on metabolic
function and immune cells among participants in a previously reported randomized …

Background Type 1 diabetes is a chronic autoimmune disease that leads to destruction of
insulin-producing beta cells and dependence on exogenous insulin for survival. Some …

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …

In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

Importance Chronic diseases have overtaken acute diseases, such as infections, as the
major cause of premature mortality worldwide. Diabetes mellitus, a chronic degenerative …

Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …

Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …

Aims/hypothesis We aimed to determine whether disease severity was reduced at onset of
clinical (stage 3) type 1 diabetes in children previously diagnosed with presymptomatic type …