Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …

Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of …

Introduction: The close relationship existing between aging and thrombosis has growingly
been studied in this last decade. The age‐related development of a prothrombotic …

The novel coronavirus disease (COVID-19) has become a universally prevalent infectious
disease. The causative virus of COVID-19 is severe acute respiratory syndrome coronavirus …

BACKGROUND: The metabolic syndrome is a constellation of common metabolic disorders
that is associated with cardiovascular disease. Insulin resistance has a central role in the …

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …

The link between plasminogen activator inhibitor (PAI)-1 and the metabolic syndrome with
obesity was established many years ago. Increased PAI-1 level can be now considered a …

Obesity, defined by an excess of adipose tissue, is often associated with the development of
various metabolic diseases. The increased and inappropriate deposition of this tissue …

Crohn's disease (CD) is an inflammatory bowel disease (IBD) with repeated remissions and
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …

Obesity, and especially excessive visceral adipose tissue accumulation, is considered as a
low-grade inflammatory state that is responsible for adipocyte dysfunction and associated …