Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Light-Induced 1H NMR Hyperpolarization in Solids at 9.4 and 21.1 T

F De Biasi, G Karthikeyan, M Visegrádi… - Journal of the …, 2024 - ACS Publications
The inherently low sensitivity of nuclear magnetic resonance (NMR) spectroscopy is the
major limiting factor for its application to elucidate structure and dynamics in solids. In the …

Multinuclear 1D and 2D NMR with 19F-Photo-CIDNP hyperpolarization in a microfluidic chip with untuned microcoil

MV Gomez, S Baas, AH Velders - Nature Communications, 2023 - nature.com
Abstract Nuclear Magnetic Resonance (NMR) spectroscopy is a most powerful molecular
characterization and quantification technique, yet two major persistent factors limit its more …

[HTML][HTML] Hyperpolarised benchtop NMR spectroscopy for analytical applications

AIS Terra, DA Taylor, ME Halse - Progress in Nuclear Magnetic Resonance …, 2024 - Elsevier
Benchtop NMR spectrometers, with moderate magnetic field strengths (B 0= 1− 2. 4 T) and
sub-ppm chemical shift resolution, are an affordable and portable alternative to standard …

Fragment Screening and Fast Micromolar Detection on a Benchtop NMR Spectrometer Boosted by Photoinduced Hyperpolarization

GR Stadler, TF Segawa, M Bütikofer… - Angewandte Chemie …, 2023 - Wiley Online Library
Fragment‐based drug design is a well‐established strategy for rational drug design, with
nuclear magnetic resonance (NMR) on high‐field spectrometers as the method of reference …

Live magnetic observation of parahydrogen hyperpolarization dynamics

J Eills, MW Mitchell, IM Rius, MCD Tayler - Proceedings of the National …, 2024 - pnas.org
Hyperpolarized nuclear spins in molecules exhibit high magnetization that is unachievable
by classical polarization techniques, making them widely used as sensors in physics …

Parallel detection of chemical reactions in a microfluidic platform using hyperpolarized nuclear magnetic resonance

J Yeste, M Azagra, MA Ortega, A Portela, G Matajsz… - Lab on a Chip, 2023 - pubs.rsc.org
The sensitivity of NMR may be enhanced by more than four orders of magnitude via
dissolution dynamic nuclear polarization (dDNP), potentially allowing real-time, in situ …

Optically Enhanced Solid-State 1H NMR Spectroscopy

F De Biasi, MA Hope, CE Avalos… - Journal of the …, 2023 - ACS Publications
Low sensitivity is the primary limitation to extending nuclear magnetic resonance (NMR)
techniques to more advanced chemical and structural studies. Photochemically induced …

Detection of sub-nmol amounts of the antiviral drug favipiravir in 19F MRI using photo-chemically induced dynamic nuclear polarization

J Bernarding, C Bruns, I Prediger, M Mützel… - Scientific Reports, 2024 - nature.com
In biological tissues, 19F magnetic resonance (MR) enables the non-invasive, background-
free detection of 19F-containing biomarkers. However, the signal-to-noise ratio (SNR) is …

Fragment‐Screening und schnelle mikromolare Detektion mit einem Benchtop‐NMR‐Spektrometer ermöglicht durch photoinduzierte Hyperpolarisation

GR Stadler, TF Segawa, M Bütikofer… - Angewandte …, 2023 - Wiley Online Library
Fragmentbasiertes Wirkstoffdesign ist eine gut etablierte Strategie für rationales
Arzneimitteldesign, wobei die Kernspinresonanzspektroskopie (NMR) auf …