Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

The historical impression that tuberculosis was an inherited disorder has come full circle and
substantial evidence now exists of the human genetic contribution to susceptibility to …

Increasing knowledge about DosR regulon-encoded proteins has led us to produce novel
Mycobacterium tuberculosis antigens for immunogenicity testing in human populations in …

The vitamin D receptor (VDR) and the human leukocyte antigen (HLA) class II complex affect
innate and/or adaptive immunity against Mycobacterium tuberculosis. HLA-DRB1, HLA …

Background. The development of active tuberculosis disease has been shown to be
multifactorial. Interactions between host and bacterial genotype may influence disease …

Toll-like receptors (TLRs) are critical mediators of the immune response to pathogens. The
influence of human TLR6 polymorphisms on susceptibility to infection is only partially …

Genetics of autoimmune diseases represent a growing domain with surpassing biomarker
results with rapid progress. The exact cause of Rheumatoid Arthritis (RA) is unknown, but it …

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is a major cause of
morbidity and mortality worldwide. Many candidate genes have been investigated for a …

Introduction In several of the Low and Middle Income countries, many patients with Type 1
diabetes (T1D) are most probably not diagnosed at all which may contribute to their low …

Chromosome 17 is known to contain TB susceptibility genes. Polymorphisms in two of these
genes, namely NOS2A and CCL2, have been associated with TB in various populations. To …