Over the past several decades, significant advances have been made in our understanding
of the basic stages and mechanisms of mammalian brain development. Studies elucidating …

Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical neurons.
To gain insight into the patterns of RGP division and neuron production, we quantitatively …

The neocortex is the part of the brain responsible for execution of higher-order brain
functions, including cognition, sensory perception, and sophisticated motor control. During …

Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …

The corpus callosum is the largest fibre tract in the brain, connecting the two cerebral
hemispheres, and thereby facilitating the integration of motor and sensory information from …

The discovery of stem cells that can generate neural tissue has raised new possibilities for
repairing the nervous system. A rush of papers proclaiming adult stem cell plasticity has …

The vast diversity of neurons and glia of the CNS is generated from a small, heterogeneous
population of progenitors that undergo transcriptional changes during development to …