Molecular biology of lung cancer: clinical implications

JE Larsen, JD Minna - Clinics in chest medicine, 2011 - chestmed.theclinics.com
Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Conducting polymer composite-based biosensing materials for the diagnosis of lung cancer: A review

HA Saputra, KA Jannath, KB Kim, DS Park… - International Journal of …, 2023 - Elsevier
The development of a simple and fast cancer detection method is crucial since early
diagnosis is a key factor in increasing survival rates for lung cancer patients. Among several …

Anti-angiogenesis therapy overcomes the innate resistance to PD-1/PD-L1 blockade in VEGFA-overexpressed mouse tumor models

Q Wang, J Gao, W Di, X Wu - Cancer Immunology, Immunotherapy, 2020 - Springer
The effectual clinical benefits of immune checkpoint inhibitor (ICI) are hampered by a high
rate of innate resistance, and VEGFA may contribute to ICI treatment resistance. In this study …

Investigation of complement activation product c4d as a diagnostic and prognostic biomarker for lung cancer

D Ajona, MJ Pajares, L Corrales… - Journal of the …, 2013 - academic.oup.com
Background There is a medical need for diagnostic biomarkers in lung cancer. We
evaluated the diagnostic performance of complement activation fragments. Methods We …

Biomarkers of angiogenesis in colorectal cancer: Supplementary issue: Biomarkers for colon cancer

L Mousa, ME Salem, S Mikhail - Biomarkers in cancer, 2015 - journals.sagepub.com
Colorectal cancer (CRC) is the third most common cancer worldwide and accounts for 10%
of all new cancer diagnoses. Angiogenesis is a tightly regulated process that is mediated by …

Targeted therapies for lung cancer: clinical experience and novel agents

JE Larsen, T Cascone, DE Gerber… - The Cancer …, 2011 - journals.lww.com
Although lung cancer remains the leading cancer killer in the United States, recently a
number of developments indicate future clinical benefit. These include evidence that …

Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer

FS Farhat, A Tfayli, N Fakhruddin, R Mahfouz… - Critical reviews in …, 2012 - Elsevier
Despite major advances in cancer therapeutics, the prognosis for lung cancer patients is still
poor and the median survival for patients presenting with advanced non-small cell lung …

Studies in lung cancer cytokine proteomics: a review

H Abolfathi, M Sheikhpour, SS Shahraeini… - Expert Review of …, 2021 - Taylor & Francis
Introduction Proteins are molecules that have role in the progression of the diseases.
Proteomics is a tool that can play an effective role in identifying diagnostic and therapeutic …

Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy

JM Jürgensmeier, HJ Schmoll, JD Robertson… - British journal of …, 2013 - nature.com
Background: The prognostic/predictive value of potential vascular endothelial growth factor
(VEGF) signalling biomarkers was evaluated retrospectively using samples from two …

Vascular endothelial growth factor a regulates the secretion of different angiogenic factors in lung cancer cells

D Frezzetti, M Gallo, C Roma… - Journal of Cellular …, 2016 - Wiley Online Library
Vascular endothelial growth factor A (VEGFA) is one of the main mediators of angiogenesis
in non‐small cell lung cancer (NSCLC). Recently, it has been described an autocrine feed …