[HTML][HTML] Statins: old drugs as new therapy for liver diseases?

E Pose, J Trebicka, RP Mookerjee, P Angeli… - Journal of hepatology, 2019 - Elsevier
In addition to lowering cholesterol levels, statins have pleiotropic effects, particularly anti-
inflammatory, antiangiogenic, and antifibrotic, that may be beneficial in some chronic …

Cirrhosis as new indication for statins

J Bosch, J Gracia-Sancho, JG Abraldes - Gut, 2020 - gut.bmj.com
In the recent years, there have been an increasing number of reports on favourable effects of
statins in patients with advanced chronic liver disease. These include reduction in portal …

Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase …

E Pose, L Napoleone, A Amin, D Campion… - The Lancet …, 2020 - thelancet.com
Background Statins have beneficial effects on intrahepatic circulation and decrease portal
hypertension and rifaximin modulates the gut microbiome and might prevent bacterial …

[HTML][HTML] Early diagnosis and prevention of infections in cirrhosis

AV Kulkarni, M Premkumar, JP Arab… - Seminars in Liver …, 2022 - thieme-connect.com
Strategies to prevent infection and improve outcomes in patients with cirrhosis. HAV,
hepatitis A virus; HBV, hepatitis B virus; COVID-19, novel coronavirus disease 2019; NSBB …

[HTML][HTML] The search for disease-modifying agents in decompensated cirrhosis: from drug repurposing to drug discovery

P Caraceni, JG Abraldes, P Ginès, PN Newsome… - Journal of …, 2021 - Elsevier
Patients with decompensated cirrhosis are currently managed through targeted strategies
aimed at preventing or treating specific complications. In contrast, a disease-modifying agent …

Statins and nonalcoholic fatty liver disease in the era of precision medicine: more friends than foes

F Nascimbeni, E Pellegrini, S Lugari, A Mondelli… - Atherosclerosis, 2019 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of alcohol-like hepatic
histological changes, which occur in the absence of any competing causes of chronic liver …

[HTML][HTML] Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial

TM Kronborg, R Schierwagen, K Trošt… - Hepatology …, 2023 - journals.lww.com
Background: Patients with cirrhosis and portal hypertension face a high risk of
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …

Emerging role of statin therapy in the prevention and management of cirrhosis, portal hypertension, and HCC

SR Sharpton, R Loomba - Hepatology, 2023 - journals.lww.com
Statins, the most widely used lipid-lowering drugs, are increasingly recognized to have
pleiotropic effects including anti-inflammatory and antiangiogenic properties as well as …

Comprehensive evaluation of effects and safety of statin on the progression of liver cirrhosis: a systematic review and meta-analysis

Y Gu, X Yang, H Liang, D Li - BMC gastroenterology, 2019 - Springer
Background Statin has been more and more widely used in chronic liver disease, however,
existed studies have attained contradictory results. According to the present study, we aimed …

Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma

H Li - Digestive and Liver Disease, 2022 - Elsevier
Intercellular crosstalk among various liver cells plays an important role in liver fibrosis,
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …