[HTML][HTML] Statins: old drugs as new therapy for liver diseases?
In addition to lowering cholesterol levels, statins have pleiotropic effects, particularly anti-
inflammatory, antiangiogenic, and antifibrotic, that may be beneficial in some chronic …
inflammatory, antiangiogenic, and antifibrotic, that may be beneficial in some chronic …
Cirrhosis as new indication for statins
In the recent years, there have been an increasing number of reports on favourable effects of
statins in patients with advanced chronic liver disease. These include reduction in portal …
statins in patients with advanced chronic liver disease. These include reduction in portal …
Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase …
E Pose, L Napoleone, A Amin, D Campion… - The Lancet …, 2020 - thelancet.com
Background Statins have beneficial effects on intrahepatic circulation and decrease portal
hypertension and rifaximin modulates the gut microbiome and might prevent bacterial …
hypertension and rifaximin modulates the gut microbiome and might prevent bacterial …
[HTML][HTML] Early diagnosis and prevention of infections in cirrhosis
Strategies to prevent infection and improve outcomes in patients with cirrhosis. HAV,
hepatitis A virus; HBV, hepatitis B virus; COVID-19, novel coronavirus disease 2019; NSBB …
hepatitis A virus; HBV, hepatitis B virus; COVID-19, novel coronavirus disease 2019; NSBB …
[HTML][HTML] The search for disease-modifying agents in decompensated cirrhosis: from drug repurposing to drug discovery
Patients with decompensated cirrhosis are currently managed through targeted strategies
aimed at preventing or treating specific complications. In contrast, a disease-modifying agent …
aimed at preventing or treating specific complications. In contrast, a disease-modifying agent …
Statins and nonalcoholic fatty liver disease in the era of precision medicine: more friends than foes
F Nascimbeni, E Pellegrini, S Lugari, A Mondelli… - Atherosclerosis, 2019 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of alcohol-like hepatic
histological changes, which occur in the absence of any competing causes of chronic liver …
histological changes, which occur in the absence of any competing causes of chronic liver …
[HTML][HTML] Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial
TM Kronborg, R Schierwagen, K Trošt… - Hepatology …, 2023 - journals.lww.com
Background: Patients with cirrhosis and portal hypertension face a high risk of
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …
Emerging role of statin therapy in the prevention and management of cirrhosis, portal hypertension, and HCC
SR Sharpton, R Loomba - Hepatology, 2023 - journals.lww.com
Statins, the most widely used lipid-lowering drugs, are increasingly recognized to have
pleiotropic effects including anti-inflammatory and antiangiogenic properties as well as …
pleiotropic effects including anti-inflammatory and antiangiogenic properties as well as …
Comprehensive evaluation of effects and safety of statin on the progression of liver cirrhosis: a systematic review and meta-analysis
Y Gu, X Yang, H Liang, D Li - BMC gastroenterology, 2019 - Springer
Background Statin has been more and more widely used in chronic liver disease, however,
existed studies have attained contradictory results. According to the present study, we aimed …
existed studies have attained contradictory results. According to the present study, we aimed …
Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma
H Li - Digestive and Liver Disease, 2022 - Elsevier
Intercellular crosstalk among various liver cells plays an important role in liver fibrosis,
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …