Background China experiences large variations in influenza seasonal activity. We aim to
update and improve the current understanding of regional-based within-year variations of …

Based on differences in the amino acid sequence of the protein haemagglutinin (HA), the
H9N2 avian influenza virus (H9N2 virus) has been clustered into multiple lineages, and its …

The constant domains of antibodies are important for effector functions, but less is known
about how they can affect binding and neutralization of viruses. Here, we evaluated a panel …

Background Interseasonal influenza outbreaks are not unusual in countries with temperate
climates and well-defined influenza seasons. Usually, these are small and diminish before …

Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and
control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide …

The spread of influenza A/H3N2 variants possessing the hemagglutinin 121 K mutation and
the unexpectedly high incidence of influenza in the 2017–2018 northern hemisphere …

The H9N2 avian influenza virus (AIV) represents a significant risk to both the poultry industry
and public health. Our surveillance efforts in China have revealed a growing trend of recent …

We previously developed a temperature-sensitive, and NS1 gene deleted live attenuated
influenza vaccine (DelNS1-LAIV) and demonstrated its potent protective efficacy in …

H9N2 virus has become the most widespread subtype of avian influenza in Chinese poultry.
Although many studies have been published on this disease, the pathogenesis of the H9N2 …

Influenza viruses continue to cause epidemics worldwide every year. However, due to the
lack of an effective assessment for the severity of influenza epidemics, it was extremely …