The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women and a
major cause of anovulatory infertility. A diagnosis of PCOS is established based the …

Increasing evidence accumulated during the past two decades has demonstrated that the
then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Estrogen produced by ovarian follicles plays a key role in the central mechanisms
controlling reproduction via regulation of gonadotropin-releasing hormone (GnRH) release …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and is the leading cause of anovulatory subfertility. Increased …

Endogenous opioid peptides have attracted attention as critical neuropeptides in the central
mechanism regulating female reproduction ever since the discovery that arcuate dynorphin …