Cancer is a highly variable disease with multiple heterogeneous genetic and epigenetic
changes. Functional studies are essential to understanding the complexity and …

Until recently, nutrition research concentrated on nutrient deficiencies and impairment of
health. The advent of genomics—interpreted broadly as a suite of high throughput …

Extracellular vesicles (EVs) secreted by cancer cells provide an important insight into cancer
biology and could be leveraged to enhance diagnostics and disease monitoring. This paper …

Purpose: Numerous studies of circulating epithelial cells (CECs) have been described in
cancer patients, and genetic abnormalities have been well documented. However, with one …

Blood is the pipeline of the immune system. Assessing changes in transcript abundance in
blood on a genome-wide scale affords a comprehensive view of the status of the immune …

Microarray techniques hold great promise for identifying risk factors for schizophrenia (SZ)
but have not yet generated widely reproducible results due to methodological differences …

Aberrant activation of the Hedgehog (HH)/GLI signaling pathway has been implicated in the
development of basal cell carcinoma (BCC). The zinc finger transcription factors GLI1 and …

The interferon (IFN) induced anti-viral response is amongst the earliest and most potent of
the innate responses to fight viral infection. The induction of the Janus kinase/signal …

Metastatic breast cancer (MBC) is considered incurable; therefore, palliative treatment is the
only option. The biologic heterogeneity of the disease is reflected in its somewhat …

Transgenic mouse models have provided evidence that activation of the zinc-finger
transcription factor GLI1 by Hedgehog (Hh)-signalling is a key step in the initiation of the …