Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities
worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown
mechanisms, induce widespread inflammation. We found that a large proportion of primary …

The bidirectional causality between kidney injury and inflammation remains an area of
unexpected discoveries. The last decade unraveled the molecular mechanisms of sterile …

To understand more about how the body recognizes alum we characterized the early innate
and adaptive responses in mice injected with the adjuvant. Within hours of exposure, alum …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

Myocardial infarction triggers an inflammatory cascade that results in healing and
replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate …

Trypsin and mast cell tryptase can signal to epithelial cells, myocytes, and nerve fibers of the
respiratory tract by cleaving proteinase-activated receptor 2 (PAR2). Since tryptase inhibitors …

Historically, mast cells were known as a key cell type involved in type I hypersensitivity. Until
last two decades, this cell type was recognized to be widely involved in a number of non …