Reactive oxygen species (ROS) are a group of highly reactive chemicals containing oxygen
produced either exogenously or endogenously. ROS are related to a wide variety of human …

Multiple roles have been indicated for reactive oxygen species (ROS) in the immune system
in recent years. ROS have been extensively studied due to their ability to damage DNA and …

With the increasing understanding of various biological functions mediated by reactive
oxygen species (ROS) in the immune system, a number of studies have been designed to …

MicroRNAs (miRNAs) are recognized as being central players in many biological processes
and cellular pathways. Their roles in disease have been highlighted first by observation of …

We previously showed that type I interferon-induced, Cre-mediated ablation of surface BCR
expression in mature B cells through Ig-heavy chain deletion results in apoptosis of these …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-
primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling …

While memory T cells are maintained by continuous turnover, it is not clear how human
regulatory CD4+ CD45RO+ CD25hi Foxp3+ T lymphocyte populations persist throughout …

Patients with sepsis are immune compromised, as evidenced by their failure to clear their
primary infection and their propensity to develop secondary infections with pathogens that …

Upon systemic activation by antigens, CD8+, but not CD4+, T cells selectively accumulate
and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic …