Generation of insulin-producing pancreatic β cells from multiple human stem cell lines
NJ Hogrebe, KG Maxwell, P Augsornworawat… - Nature protocols, 2021 - nature.com
We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …
[HTML][HTML] The versatile functions of Sox9 in development, stem cells, and human diseases
A Jo, S Denduluri, B Zhang, Z Wang, L Yin, Z Yan… - Genes & diseases, 2014 - Elsevier
The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin… - Nature …, 2014 - nature.com
Transplantation of pancreatic progenitors or insulin-secreting cells derived from human
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …
Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas
Extracellular matrix (ECM) plays an important developmental role by regulating cell
behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained …
behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained …
Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
Directed differentiation of human pluripotent stem cells into functional insulin‐producing
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …
Efficient generation of functional pancreatic β‐cells from human induced pluripotent stem cells: 人类诱导性多能干细胞可有效生成有功能的胰腺β 细胞
SG Yabe, S Fukuda, F Takeda, K Nashiro… - Journal of …, 2017 - Wiley Online Library
Background Insulin‐secreting cells have been generated from human embryonic or induced
pluripotent stem cells (iPSCs) by mimicking developmental processes. However, these cells …
pluripotent stem cells (iPSCs) by mimicking developmental processes. However, these cells …
Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
Pancreas organogenesis: from lineage determination to morphogenesis
The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …
and exocrine function. In the past two decades, knowledge of how the pancreas develops …
Generation of pancreatic β cells for treatment of diabetes: advances and challenges
Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …
Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
Aims/hypothesis Islet transplantation is a promising cell therapy for patients with diabetes,
but it is currently limited by the reliance upon cadaveric donor tissue. We previously …
but it is currently limited by the reliance upon cadaveric donor tissue. We previously …