Background Breast cancer (BC) is the second most frequent type of cancer in the world and
most common among women, configuring a major challenge to global health. BC is a …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Bone is the most common site of breast cancer metastasis. Bone metastasis is incurable and
is associated with severe morbidity. Utilizing an immunocompetent mouse model of …

Breast cancer (BC) is the most common cancer among women worldwide and the main
cause of cancer deaths in women. Metabolic components are key risk factors for the …

It remains unclear whether metronomic chemotherapy is superior to conventional
chemotherapy when combined with immune checkpoint blockade. Here we performed a …

Simple Summary While tumor-associated macrophages (TAMs) are known to be associated
with a poor prognosis in breast cancer (BC) in general, how they influence different BC …

The endocytic trafficking pathway is a highly organized cellular program responsible for the
regulation of membrane components and uptake of extracellular substances. Molecules …

Background Immune‐checkpoint blockade (ICB) therapy shows promise for treating
aggressive triple‐negative breast cancer (TNBC). However, only some patients benefit from …

Betulinic acid (BA) is a pentacyclic triterpene compound, which can be obtained by
separation, chemical synthesis and biotransformation. BA has excellent biological activities …

Breast cancer remains a significant clinical concern affecting millions of women worldwide.
Immunotherapy is a rapidly growing drug class that has revolutionized cancer treatment but …