Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's
disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms …

Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β
peptide drives cerebral neuroinflammation by activating microglia,. Indeed, amyloid-β …

Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …

Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …

Alzheimer's disease is the most frequent neurodegenerative disorder and the most common
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …

The occurrence of cognitive disturbances upon CNS inflammation or infection has been
correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date …