Merkel cell carcinoma and the eye

R Valentini, JM Grant-Kels, M Falcone, CL Stewart - Clinics in Dermatology, 2024 - Elsevier
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor with a poor five-
year survival rate. Yearly cases have risen nearly 350% since the early 1980s, and these …

New targeted therapies and immunotherapies for locally advanced periocular malignant tumours: Towards a new 'eye-sparing'paradigm?

A Martel, S Lassalle, A Picard-Gauci, L Gastaud… - Cancers, 2021 - mdpi.com
Simple Summary Managing locally advanced periocular malignant tumours, especially
those invading the orbit, is challenging. Orbital exenteration has long been considered the …

An effective primary treatment using radiotherapy in patients with eyelid Merkel cell carcinoma

M Boileau, M Dubois, H Abi Rached, A Escande… - Current …, 2023 - mdpi.com
Background: Merkel cell carcinoma (MCC) is a rare type of neuroendocrine tumor. Palpebral
localization represents 2.5% of MCCs. Surgery is not always possible due to the localization …

[HTML][HTML] Prevalence of Merkel Cell Polyomavirus in Primary Eyelid Merkel Cell Carcinomas and Association With Clinicopathological Features

H Komatsu, Y Usui, A Sukeda, Y Yamamoto… - American Journal of …, 2023 - Elsevier
Purpose Merkel cell polyomavirus (MCPyV) infection is a known to be a critical risk factor for
the development of Merkel cell carcinoma (MCC). Various reports on cutaneous MCC have …

Elevated levels of Merkel cell polyoma virus in the anophthalmic conjunctiva

N Siegal, M Gutowski, L Akileswaran… - Scientific Reports, 2021 - nature.com
The human ocular surface hosts a paucibacterial resident microbiome and virome. The
factors contributing to homeostasis of this mucosal community are presently unknown. To …

Merkel cell carcinoma of the eyelid and periocular region: A review

NM Walsh - Saudi Journal of Ophthalmology, 2021 - journals.lww.com
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with a
high mortality rate. It typically affects elderly Caucasians, with a slight predilection for males …

Comparison of Quantitative Real-Time PCR and Digital PCR to Detect the Polyomavirus in Merkel Cell Carcinoma

M Barchitta, A Maugeri, E Campisi, R Magnano San Lio… - Viruses, 2022 - mdpi.com
Merkel cell polyomavirus (MCPyV) prevalence in Merkel cell carcinoma (MCC) cases is
controversial. The detection and quantification of MCPyV DNA is mainly performed by PCR …

Adverse Event Assessment of Upadacitinib: A Pharmacovigilance Study Based on the FAERS Database

J Yuan, HX Lu, X Zuo, L Yin, Y Pu… - … and Drug Safety, 2024 - Wiley Online Library
ABSTRACT Purpose Upadacitinib, a Janus kinase (JAK) inhibitor, has been approved by
the FDA to treat various autoimmune conditions. This study assessed its adverse events by …

Eyelid tumors of apocrine, eccrine, and pilar origins

R Rodgers, FA Jakobiec, A Sheikh - Albert and Jakobiec's Principles and …, 2020 - Springer
This chapter summarizes sweat gland and hair follicle tumors affecting the eyelids, brows,
and temples. The normal apocrine and eccrine apparatus are defined, followed by a …

Clinical Signs for Differential Diagnosis of Eyelid Tumours

A Kopecky, AC Rokohl, PJ Gaca… - Klinische …, 2023 - thieme-connect.com
This article aims to present the differential diagnostics of benign and malignant eyelid
tumours. The most common malignant eyelid tumour is basal cell carcinoma, followed by …