[HTML][HTML] The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications
Although neurons attract the most attention in neurobiology, our current knowledge of neural
circuit can only partially explain the neurological and psychiatric conditions of the brain …
circuit can only partially explain the neurological and psychiatric conditions of the brain …
The neurochemical profile quantified by in vivo 1H NMR spectroscopy
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …
research as an important tool for evidence based diagnosis and therapy monitoring. It …
Mitochondria as a therapeutic target for aging and neurodegenerative diseases
PH Reddy, TP Reddy - Current Alzheimer Research, 2011 - ingentaconnect.com
Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence
from animal models, postmortem brain studies of and clinical studies of aging and …
from animal models, postmortem brain studies of and clinical studies of aging and …
Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington's disease
Till date, an exact causative pathway responsible for neurodegeneration in Huntington's
disease (HD) remains elusive; however, mitochondrial dysfunction appears to play an …
disease (HD) remains elusive; however, mitochondrial dysfunction appears to play an …
[HTML][HTML] Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease
PH Reddy, UP Shirendeb - Biochimica et Biophysica Acta (BBA)-Molecular …, 2012 - Elsevier
Huntington's disease (HD) is a progressive, fatal neurodegenerative disease caused by
expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures …
expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures …
Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington's disease
Objective: The objective of the present study was to investigate the potential use of solid lipid
nanoparticles (SLNs) as a drug delivery system to enhance the brain-targeting efficiency of …
nanoparticles (SLNs) as a drug delivery system to enhance the brain-targeting efficiency of …
Mitochondrial structural and functional dynamics in Huntington's disease
PH Reddy, P Mao, M Manczak - Brain research reviews, 2009 - Elsevier
Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative
disorder, characterized by chorea, involuntary movements, and cognitive impairments …
disorder, characterized by chorea, involuntary movements, and cognitive impairments …
Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system
R Sandhir, A Mehrotra, SS Kamboj - Neurochemistry International, 2010 - Elsevier
3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinic acid dehydrogenase (SDH),
induces neurodegeneration similar to that observed in Huntington's disease (HD). The …
induces neurodegeneration similar to that observed in Huntington's disease (HD). The …
Mitochondria and the brain: bioenergetics and beyond
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate.
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …
Mitochondrial mechanisms of estrogen neuroprotection
JW Simpkins, JA Dykens - Brain research reviews, 2008 - Elsevier
Oxidative stress, bioenergetic failure and mitochondrial dysfunction are all implicated in the
etiology of neurodegenerative diseases such as Alzheimer's disease (AD). The …
etiology of neurodegenerative diseases such as Alzheimer's disease (AD). The …