Caesalpinia sappan and Haematoxylum brasiletto belong to the Fabaceae family,
predominantly distributed in Southeast Asia and America. The isoflavonoid brazilin has …

The interplay between α-synuclein (α-syn) and catechols plays a central role in Parkinson's
disease. This may be related to the modulating effects of catechols on the various aspects of …

Background Neuronal uptake and subsequent spread of proteopathic seeds, such as αS
(alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular …

The pathological assembly of intrinsically disordered proteins/peptides (IDPs) into amyloid
fibrils is associated with a range of human pathologies, including neurodegeneration …

The aggregation of α‐synuclein (α‐Syn) is a critical pathological hallmark of Parkinson's
disease (PD). Prevention of α‐Syn aggregation has become a key strategy for treating PD …

α-Synuclein (α-syn) aggregates into cytotoxic amyloid fibrils, which are recognized as the
defining neuropathological feature of Parkinson's disease (PD). Therefore, inhibiting α-syn …

The tenacious biofilms formed by Streptococcus mutans are resistant to conventional
antibiotics and current treatments. There is a growing need for novel therapeutics that …

The tetracyclic phenolic compound brazilin, derived from the wood of Caesalpinia sappan,
has been shown to bind to the chromatin protein BAF1 (barrier‐to‐autointegration factor 1) …

Abstract α-Synuclein (αS) is an intrinsically disordered protein (IDP) that aggregates into
amyloid fibrils during the progression of Parkinson's Disease and other synucleinopathies …

Uptake and spread of proteopathic seeds, such as αS, Tau, and TDP-43, contribute to
neurodegeneration. The cellular machinery necessary for this process is poorly understood …