Due to the lack of success in small-diameter (< 6 mm) prosthetic vascular grafts, a variety of
strategies have evolved utilizing a tissue-engineering approach. Much of this work has …

Cardiovascular calcification is a commonly observed but incompletely understood
mechanism of increased atherosclerotic plaque instability and accelerated aortic valve …

Recently our group demonstrated that acellular tissue engineered vessels (A-TEVs)
comprised of small intestinal submucosa (SIS) immobilized with heparin and vascular …

Porcine extracellular matrix (pECM)-derived hydrogels were introduced, in recent years,
aiming to benefit the pECM's microstructure and bioactivity, while controlling the …

Recently, our group demonstrated that immobilized VEGF can capture flowing endothelial
cells (ECs) from the blood in vitro and promote endothelialization and patency of acellular …

Each year, hundreds of thousands coronary bypass procedures are performed in the US, yet
there currently exists no off-the-shelf alternative to autologous vessel transplant. In the …

Atherosclerosis and its complications still represent the leading cause of death in the
developed countries. While autologous blood vessels may be regarded as the best solution …

Effective cellularization is a key approach to prevent small-caliber (< 4 mm) tissue-
engineered vascular graft (TEVG) failure and maintain patency and contractility following …

The field of anatomic pathology has changed significantly over the last decades and, as a
result of the technological developments in molecular pathology and genetics, has had …

Background Nitric oxide is a chemical agent produced by endothelial cells in a healthy
blood vessel, inhibiting the overgrowth of vascular smooth muscle cells and regulating …