Recent milestones in the understanding of gastric acid secretion and treatment of acid-
peptic disorders include the (1) discovery of histamine H2-receptors and development of …

Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …

Background Vonoprazan (V), a potassium‐competitive acid blocker, has a more durable
acid‐inhibitory effect as compared with standard‐dose proton pump inhibitors (PPIs) but has …

Background & Aims Acid secretion inhibitors are associated with hypergastrinemia, which
can lead to gastric mucosal changes. Potassium-competitive acid blockers, such as …

Pharmacological agents, such as histamine H2 receptor antagonists and acid pump
inhibitors, are now the most frequently used treatment for such acid-related diseases as …

We continue to make progress in our understanding of the regulation of gastric acid
secretion in health and disease. A better understanding of the pathways and mechanisms …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide widely
distributed in the central nervous system (CNS) and many peripheral organs, such as the …

The purpose of this review, based upon 40 years of research, is to clear old controversies.
The gastric juice is a strong acid with active enzymes (pepsin and lipase); ideal for killing …

An improved understanding of the pathways and mechanisms regulating gastric acid
secretion should lead to the development of novel therapies to prevent and treat acid-peptic …

Pituitary adenylate cyclase-activating peptide (PACAP) is a highly conserved and widely
expressed neuropeptide that has emerged as a key regulator of multiple neural and …