Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which
exhibit some symptom similarities and are thus considered to share a common etiology. The …

Abstract Purpose of Review The prevalence of diabetes mellitus and its chronic
complications are increasing to epidemic proportions. This will unfortunately result in …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Adipose tissue is recognized as an active endocrine organ that produces a number of
endocrine substances referred to as “adipokines” including leptin, adiponectin, adipolin …

There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

Diabetes and hyperglycemia create a proinflammatory microenvironment that progresses to
microvascular complications such as nephropathy, retinopathy, and neuropathy. Diet …

There has been an exponential rise in diabetes mellitus (DM) cases on a global scale.
Diabetes affects almost every system of the body, and the nervous system is no exception …