The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
[HTML][HTML] Current senolytics: mode of action, efficacy and limitations, and their future
AN Rad, J Grillari - Mechanisms of Ageing and Development, 2023 - Elsevier
Senescence is a cellular state characterized by its near-permanent halted cell cycle and
distinct secretory phenotype. Although senescent cells have a variety of beneficial …
distinct secretory phenotype. Although senescent cells have a variety of beneficial …
[HTML][HTML] Nutritional components as mitigators of cellular senescence in organismal aging: A comprehensive review
B Diwan, R Sharma - Food Science and Biotechnology, 2022 - Springer
The process of cellular senescence is rapidly emerging as a modulator of organismal aging
and disease. Targeting the development and removal of senescent cells is considered a …
and disease. Targeting the development and removal of senescent cells is considered a …
Cellular senescence: beneficial, harmful, and highly complex
DJ Baker, M Narita, P Muñoz‐Cánoves - The FEBS Journal, 2023 - Wiley Online Library
The contribution of cellular senescence to a diverse range of biological processes, including
normal physiology, ageing, and pathology were long overlooked but have now taken centre …
normal physiology, ageing, and pathology were long overlooked but have now taken centre …
[HTML][HTML] Lifestyle interventions to delay senescence
J Martel, DM Ojcius, JD Young - Biomedical Journal, 2024 - Elsevier
Senescence is a condition of cell cycle arrest that increases inflammation and contributes to
the development of chronic diseases in the aging human body. While several compounds …
the development of chronic diseases in the aging human body. While several compounds …
Lipids and the hallmarks of ageing: from pathology to interventions
R Sharma, B Diwan - Mechanisms of Ageing and Development, 2023 - Elsevier
Lipids are critical structural and functional architects of cellular homeostasis. Change in
systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and …
systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and …
[HTML][HTML] Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults
Regular endurance exercise training is an effective intervention for the maintenance of
metabolic health and the prevention of many age-associated chronic diseases. Several …
metabolic health and the prevention of many age-associated chronic diseases. Several …
[HTML][HTML] The effects of macronutrients metabolism on cellular and organismal aging
Evidence supports the notion that metabolic pathways are major regulators of organismal
aging, and that metabolic perturbations can extend health-and lifespan. For this reason …
aging, and that metabolic perturbations can extend health-and lifespan. For this reason …
[HTML][HTML] Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice
A variety of inbred mouse strains have been used for research in metabolic disorders.
Despite being inbred, they display large inter-individual variability for many traits like food …
Despite being inbred, they display large inter-individual variability for many traits like food …
Nutrition and stem cell integrity in aging
Adult stem cells (SCs) represent the regenerative capacity of organisms throughout their
lifespan. The maintenance of robust SC populations capable of renewing organs and …
lifespan. The maintenance of robust SC populations capable of renewing organs and …