The synapse is the focus of experimental research and theory on the cellular mechanisms of
nervous system plasticity and learning, but recent research is expanding the consideration …

Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the developing central nervous system (CNS) …

The adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2+
cells) that generate oligodendrocytes and repair myelin, but how these ubiquitous …

Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …

Activity-dependent myelination is thought to contribute to adaptive neurological function.
However, the mechanisms by which activity regulates myelination and the extent to which …

Structural plasticity in the myelinated infrastructure of the nervous system has come to light.
Although an innate program of myelin development proceeds independent of nervous …

Despite the importance of myelin for the rapid conduction of action potentials, the molecular
bases of oligodendrocyte differentiation and central nervous system (CNS) myelination are …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is
controlled by complex cell-cell signaling that regulates oligodendrocyte development and …

Myelin regeneration can occur spontaneously in demyelinating diseases such as multiple
sclerosis (MS). However, the underlying mechanisms and causes of its frequent failure …