[HTML][HTML] Advances in the regulation of mammalian follicle-stimulating hormone secretion

HQ Wang, WD Zhang, B Yuan, JB Zhang - Animals, 2021 - mdpi.com
Simple Summary The reproduction of mammals is regulated by the hypothalamic-pituitary-
gonadal axis. Follicle stimulating hormone, as one of the gonadotropins secreted by the …

Gonadotropin-releasing hormone analogs: Mechanisms of action and clinical applications in female reproduction

HM Wu, HM Chang, PCK Leung - Frontiers in neuroendocrinology, 2021 - Elsevier
Extra-hypothalamic GnRH and extra-pituitary GnRH receptors exist in multiple human
reproductive tissues, including the ovary, endometrium and myometrium. Recently, new …

[HTML][HTML] β-arrestin 2 is a prognostic factor for survival of ovarian cancer patients upregulating cell proliferation

B Czogalla, A Partenheimer, U Jeschke… - Frontiers in …, 2020 - frontiersin.org
Establishing reliable prognostic factors as well as specific targets for new therapeutic
approaches is an urgent requirement in advanced ovarian cancer. For several tumor …

Two human menopausal gonadotrophin (hMG) preparations display different early signaling in vitro

L Casarini, L Riccetti, E Paradiso… - Molecular Human …, 2020 - academic.oup.com
Commercial hMG drugs are marketed for the treatment of infertility and consist of highly
purified hormones acting on receptors expressed in target gonadal cells. Menopur® and …

[HTML][HTML] Current Insights in Prolactin Signaling and Ovulatory Function

D Szukiewicz - International Journal of Molecular Sciences, 2024 - mdpi.com
Prolactin (PRL) is a pleiotropic hormone released from lactotrophic cells of the anterior
pituitary gland that also originates from extrapituitary sources and plays an important role in …

Pharmacokinetic, safety, and pharmacodynamic properties of teverelix trifluoroacetate, a novel gonadotropin‐releasing hormone antagonist, in healthy adult subjects

CM MacLean, Z Godsafe, P Soto‐Forte… - … in Drug Development, 2022 - Wiley Online Library
Teverelix trifluoroacetate is a decapeptide, gonadotropin‐releasing hormone antagonist that
binds competitively and reversibly to gonadotropin‐releasing hormone receptors in the …

[HTML][HTML] A partial loss-of-function variant in GNRNR gene in a Chinese cohort with idiopathic hypogonadotropic hypogonadism

Y Chen, T Sun, Y Niu, D Wang, K Liu… - Translational …, 2021 - ncbi.nlm.nih.gov
Background Idiopathic hypogonadotropic hypogonadism (IHH) is a rare genetic disease
attributed to the disorder of hypothalamic-pituitary-gonadal axis. Mutations in the GNRHR …

Current Insights in Prolactin Signaling and Ovulatory Function in Health and Disease

D Szukiewicz - 2024 - preprints.org
Prolactin (PRL) is a pleiotropic hormone released from lactotrophic cells of the anterior
pituitary gland that also originates from extrapituitary sources and plays an important role in …

Intergalactic Interactions-Network Biology in Rodents from Spaceflight and Terra Firma

SM Hacking, ZE Sargin - 2023 - researchsquare.com
This study, utilizing data from the NASA Gene Lab Data Repository, investigates the impact
of spaceflight on rodents, analyzing changes in lung, colorectal, and skin tissues. We …

Safe and Effective Kinase Inhibitors for the Treatment of Gynecological Cancers: In Silico Approach

VM Patil, A Kumar, V Anand, P Bansal… - Current Drug …, 2021 - ingentaconnect.com
Aims: This study aimed at studying various types of gynecological cancers and the available
therapeutics to investigate safe and effective drugs. Background: Cancer is the most …