Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Neutrophils have traditionally been viewed as bystanders or biomarkers of cardiovascular
disease. However, studies in the past decade have demonstrated the important functions of …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Abstract Evaluation of coronary artery disease (CAD) using coronary computed tomography
angiography (CCTA) has seen a paradigm shift in the last decade. Evidence increasingly …

Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Neutrophil dysregulation is implicated in the pathogenesis of systemic lupus erythematosus
(SLE). SLE is characterized by elevated levels of a pathogenic neutrophil subset known as …